Recent Advances: Rheumatology

Some Recent Advances in Rheumatology

Although rheumatic problems are not fatal, they are among the more frequent causes of morbidity and long term disability in the population. They range in severity from minor aches and pains affecting the joints and related structures, to serious and potentially fatal conditions. Most of the rheumatological patients have to be followed up and given treatment on a chronic basis. Accordingly, rheu...

Clinical review Recent advances Rheumatology

Diet Cross sectional studies and studies of longitudinal cohorts have shown that obesity increases the risk of osteoarthritis of the knee in both men and women, primarily by increasing forces across the knee. An imbalance of growth factors affecting the cartilage and underlying bone may also contribute. Weight loss reduces symptoms as well as improving functional ability. High vitamin C intake ...

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

Advances in pediatric rheumatology

RECENT ADVANCES Recent advances in cystic fibrosis

The median life expectancy for cystic fibrosis is now over 30 years, and it is projected that in newborn infants it will become more than 40 years. The identification of the cystic fibrosis gene and its product, cystic fibrosis transmembrane conductance regulator (CFTR), has widened the spectrum of the disease from the classical case of the infant with cystic fibrosis to the elderly childless m...